Antimuscarinic Effects of (R)- and (S)-Oxyphencyclimine Hydrochloride |
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| Authors: | Schjelderup Lise Kozlowski Michael R. Weissman Albert Aasen Arne J. |
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| Affiliation: | (1) Department of Chemistry, The Agricultural University of Norway, Box 30, N 1432 !["angst"]("/content/n896137711247q82/xlarge8491.gif") s-NLH, Norway;(2) Bristol-Myers Company, Wallingford, Connecticut, 06492;(3) Pfizer Central Research, Groton, Connecticut, 06340 |
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| Abstract: | The (R)-( + )- and (S)-( – )-enantiomers of the anticholinergic compound, oxyphencyclimine, were synthesized from (R)-( – )- and (S)-( + )-2-cyclohexyl-2-hydroxy-2-phenylethanoic acid, respectively. The potencies of the enantiomers were compared using a cholinergic receptor binding assay. The (R)-( + )-enantiomer inhibited binding 29 times more potently than the (S)-( – )-enantiomer. |
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| Keywords: | Oxyphencyclimine enantiomers anticholinergic antimuscarinic activity |
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