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| P38信号通路与糖尿病特有因素关系的探讨 | |
| 引用本文： | 李艳波,邓华聪,郑丹,李呼伦.P38信号通路与糖尿病特有因素关系的探讨[J].中国现代医学杂志,2003,13(10):14-15,19. |
| 作者姓名： | 李艳波 邓华聪 郑丹 李呼伦 |
| 作者单位： | 1. 哈尔滨医科大学第一临床医学院内分泌科,150001 2. 重庆医科大学附属一院内分泌科,400016 3. 哈尔滨医科大学微生物教研室,哈尔滨,150086 |
| 基金项目： | 国家自然科学基金资助项目 (395 70 34 4 ) |
| 摘 要： | 目的：探讨P38信号通路(P38MAPK)在糖尿病大血管并发症中的作用。方法：分别以糖尿病特有因素：高葡萄糖、糖基化终产物(AGEs)、高胰岛素和过氧化氢刺激人脐静脉内皮细胞(HUVECs)，观察HUVECs P38MAPK磷酸化蛋白表达。结果：高葡萄糖、AGES、高胰岛素和过氧化氢均可做为独立因素激活P38MAPK，使其磷酸化表达量增加。结论：高葡萄糖、AGES生成增多、高胰岛素和氧化应激是糖尿病患者合并大血管并发症的易患因素；P38MAPK可能在糖尿病大血管并发症的发生、发展中起关键作用。 |
| 关 键 词： | P38信号通路糖尿病 大血管并发症人脐静脉内皮细胞 |
STUDY OF THE RELATIONSHIP BETWEEN P38 MITOGEN-ACTIVED PROTEIN KINASE AND DIABETIC CHARACTERISTIC FACTORS |
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| Li Yanbo,Deng Huacong,Zheng Dan.STUDY OF THE RELATIONSHIP BETWEEN P38 MITOGEN-ACTIVED PROTEIN KINASE AND DIABETIC CHARACTERISTIC FACTORS[J].China Journal of Modern Medicine,2003,13(10):14-15,19. | |
| Authors: | Li Yanbo Deng Huacong Zheng Dan |
| Institution: | Li Yanbo,Deng Huacong,Zheng Dan Department of Endocriology,The first Affiliated Hospital of Chongqing University of Medical Science,Chongqing 400016 Li Hulun Department of micbiology,Haerbin Medical University,Haerbin 150086 |
| Abstract: | Objective:To study the role of P38 mitogen-actived protein kinase (P38MAPK) on diabetic cardiovascular complication.Methods:Human umibilical vein endothelial cells (HUVECs) were separately incubated with high glucose,advanced glycosylation end products (AGEs), high insulin and H 2O 2, the expression of P38MAPK was detected.Results:High glucose, AGEs, high insulin and H 2O 2 can activate P38MAPK and increase the expression of phospho-P38MAPK significantly.Conclusion:Diabetes is associated with significantly increased prevalence of cardiovascular complications because of hyperglycemia, AGEs, hypermsutinemia and/or insulin resistance and oxidant stress; P38MAPK may play a key role in the development of diabetic cardiovascularcomplication. |
| Keywords: | P38 Mitogen-actived Protein Kinase Diabetes Mellitus Cardiovascular Complication Human Umibilical Vein Endothelial Cell |
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