跨颅磁刺激观察前额叶皮层在学习记忆中的作用

目的为了探讨前额叶皮层的功能。方法在被试进行联合搜索作业(conjunction search task)时,使用跨颅磁刺激干扰被试者右侧前额叶皮层的活动,观察被试者在训练前后反应时间的变化。结果发现磁刺激干扰前额叶的活动,明显地延长了被试者在训练前的反应时间,对训练之后的反应时间几乎没有变化。结论这说明右侧前额叶参与了记忆的编码,对记忆的提取没有作用。

Role of prefrontal cortex in learning and memory with transcranial magnetic stimulation

Objective To probe into the function of prefrontal cortex in learning and memory. Methods Transcranial magnetic stimulation (IMS) was applied over the right dorsolateral prefrontal cortex, while the subjects were doing conjunction tasks. Results TMS increased the reaction time for the naive subjects but not for non-naives. Conclusion Right dorsolateral prefrontal cortex play an essential role in learning but not in memory; or dorslateral preforntal cortex play a role in memory encoding but not in retrieving.