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| 急性白血病患者p53和bcl-2表达的临床意义 | |
| 引用本文： | 许小平,史剑慧,程文英,罗伟华,王健民,闵碧荷,丁训杰. 急性白血病患者p53和bcl-2表达的临床意义[J]. 第二军医大学学报, 2000, 21(3): 233-235 |
| 作者姓名： | 许小平 史剑慧 程文英 罗伟华 王健民 闵碧荷 丁训杰 |
| 作者单位： | 1. 第二军医大学长海医院血液科,上海,200433 2. 上海医科大学放射医学研究所 3. 华山医院血液学研究室 |
| 基金项目： | 上海市科技发展基金!( 9445 12 0 0 6) |
| 摘 要： | 目的；探讨急性白血病患者骨髓细胞Ｐ５３，ｂｃｌ－２基因表达水平与化疗预后的关系。方法；用免疫组化法测定了４２例急性白血病初发患者的骨髓细胞Ｐ５３，ｂｃｌ－２表达水平，并分析随访组（２７例）两者表达水平与化疗预后的关系。１０例务液系统良性疾病患者作为对照。结果；４２例患者Ｐ５３和ｂｃｌ－２总体表达水平显著高于对照组。在２７例可随访疗效的急性白血病患者中，Ｐ５３、ｂｃｌ－２均为阳性者完全缓解（ＣＲ）率 |
| 关 键 词： | 急性白血病 预后 p53基因 bcl－2基因 基因表达 |
| 修稿时间： | 】 |
Clinical value of p53 and bcl-2 genes expression in acute leukemia |
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| XU Xiao-Ping,SHI Jian-Hui,CHENG Wen-Ying,LUO Wei-Hua,WANG Jian-Min,MIN Bi-He,DING Xun-Jie. Clinical value of p53 and bcl-2 genes expression in acute leukemia[J]. Former Academic Journal of Second Military Medical University, 2000, 21(3): 233-235 | |
| Authors: | XU Xiao-Ping SHI Jian-Hui CHENG Wen-Ying LUO Wei-Hua WANG Jian-Min MIN Bi-He DING Xun-Jie |
| Abstract: | Objective: To explore the relationship between expression levels of p53 and bcl 2 genes in acute leukemic cells and chemotherapeutical prognosis in patients with acute leukemia. Methods: The expression levels of p53 and bcl 2 genes in 42 patients were measured by immunohistochemical assays. The relationship between the expression levels of the genes and chemotherapeutical prognosis was analyzed in follow up group. Results: The expression levels of patients with acute leukemia were higher than that of the control. In twenty seven patients with acute leukemia who had been followed up, the patients with lower expression levels of p53 and bcl 2 had more chance of complete remission(CR) than that patients with higher expression levels. Conclusion: The detection of the expression levels of p53 and bcl 2 genes in patients with acute leukemia can help to predict the chemotherapeutical effect. |
| Keywords: | leukemia acute genes p53 genes bcl 2 prognosis |
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