Desensitization to DNFB in hairless mice |
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| Authors: | M C Copeman |
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| Institution: | Clinical Immunology Research Centre, University of Sydney, New South Wales, Australia. |
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| Abstract: | Naive hairless mice may be rendered partly tolerant to dinitrofluorobenzene (DNFB) by painting DNFB on skin irradiated with 30 mJ.cm-2 ultraviolet B light (UVB) over 4 days. However, DNFB-sensitized hairless mice show no decrease in sensitivity when repainted with DNFB on skin irradiated with the same dose of UVB. Hence, established hypersensitivity appears not to be reduced by this method of inducing tolerance in naive mice. |
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| Keywords: | Hairless mice contact hypersensitivity ultraviolet B irradiation immune tolerance |
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