肝素与纳络酮治疗慢性阻塞性肺疾病合并II型呼吸衰竭的临床分析

目的观察肝素、纳络酮在治疗慢性阻塞性肺疾病(COPD)合并II型呼吸衰竭中的疗效。方法选择临床合乎标准的病例52例,按照平行随机对照方法分为2组,即观察组和对照组,每组26例。观察组用肝素、纳洛酮,肝素钠6250U加入250ml的生理盐水静滴,每日1次,7~15d为1疗程;纳络酮先开始0.4mg静脉推注,然后0.8~1.2mg加入250ml的生理盐水静滴,维持到神志转清,以后每日1次静滴,疗程同前。对照组给予常规呼吸兴奋剂。结果观察组在临床缓解和住院时间上均较对照组明显缩短,差异有显著意义(P<0.05)。结论在治疗COPD并II型呼吸衰竭患者时,使用肝素和纳络酮联合治疗,可取得比较好的疗效。

Observation of combination of heparin and naloxone on the treatment of type II respiratory failure of chronic obstructive pulmonary disease

Objective To observe the clinical effect of heparin and naloxone for the treatment of type II respiratory failure of chronic obstructive pulmonary disease (COPD).Methods 52 certified patients were selected and divided into two groups according to parallelism and random,treatment group and control group,26 patients in each group respectively.In treatment group heparin sodium 6 250 U to sodium chloride 250 ml and intraveneous drop,later inject once a day,7～15 days for the course of treatment;at the same time,at first inject naloxone 0.4 mg intraveneous and then add up 0.8～1.2 mg to 250 ml of sodium chloride intraveneous drop,then keep up till patient come to himself,later inject naloxone once a day,a course needs about 7～15 days.Patients in control group were treated by routine therapy.Result The treatment group was obviously shorter than the control group in the length of stay and the time of clinical relieve.There were significat difference between the two groups (P<0.05).Conclusion The combination of heparin and naloxone is effective for the treatment of type II respiratory failure of COPD.