血府逐瘀汤对犬冠状动脉临界狭窄血流动力学的影响

在 12条麻醉开胸犬上 ,用微米狭窄器造成冠状动脉前降支临界狭窄。测定平均动脉压 （MAP）、左心室收缩压 （L VSP）、左心室舒张压 （L VDP）、室内压最大上升速率 （+ dp/dtmax）、室内压最大下降速率 （- dp/dtmax）及心排出量 （CO）等血流动力学指标 ,在冠脉临界狭窄基础上 ,观察用血府逐瘀汤前后心功能的改变。结果表明 :冠脉临界狭窄时 ,L VDP明显升高 （P<0 .0 5 ） ,L VSP,+ dp/dtmax、- dp/dtmax及 CO明显降低 （P<0 .0 5 ） ,给血府逐瘀汤后 ,上述指标明显好转 ,表明心肌缺血造成的心脏功能损害减轻

Effects of xuefuzhuyutang on cardiac haemodynamics in coronary artery critical stenosis in dogs

In 12 open chest mongrel dogs coronary artery critical stenosis were produced by a micrometer constrictor on anterior descending coronary artery. The effects of xuefuzhuyutang on the myocardial ischemia model was observed by measuring the mean artery pressure (MAP), the left ventricular diastolic pressure (LVDP), maximal rise in left ventricular pressure (d p /d t max ),maximal fall in left ventricular pressure (-d p /d t max ) and the cardiac output (CO)etc. The results showed that the LVDP was significantly increased and the MAP,CO,d p /d t max and -d p /d t max were lowered during the period of coronary artery critical stenosis. By taking xuefuzhnyutang in the mediacted group,cardiac function was significantly improved.