角膜伤口愈合机制对准分子激光角膜屈光手术的启示

角膜伤口愈合反应是由细胞因子、生长因子、趋化因子介导的复杂级联反应。角膜上皮细胞和基底膜在这一过程中起了重要的作用,而这二者在准分子激光角膜屈光手术中常常被损伤。因此,深刻理解角膜伤口愈合过程以及并发症产生的原因,对提高准分子激光角膜屈光手术的有效性和安全性具有重要意义。就角膜伤口愈合过程及其机制进行综述。

Enlightenment from corneal wound healing for excimer laser refractive surgery

Wound healing in the human cornea has distinctive characteristics in comparison to most other tissues in the body.The corneal wound healing response is a remarkably complex cascade mediated by cytokines,growth factors,and chemokines.The interactions in the epithelial,stromal,neural,lacrimal gland,immune cells are interwoven in the corneal response to injury.Corneal epithelial cells and basement membrane play important roles in this process.However,both of them are usually impaired during the procedures of excimer laser refractive surgery for myopia,hyperopia,or astigmatism,and complications such as overcorrection,undercorrection,regression,refractive instability,and haze may occur after surgery.A complete corneal wound healing process,the biologic and molecular processes that contribute to the healing response,and anomalies that lead to complications are critical for improving the efficacy and safety of excimer laser refractive surgical procedures.