| 环氧化酶在非甾体类药物抗伤害效应中的作用 |
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| 引用本文： | 卢国林,林财珠. 环氧化酶在非甾体类药物抗伤害效应中的作用[J]. 医学综述, 2008, 14(13): 2039-2041 |
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| 作者姓名： | 卢国林 林财珠 |
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| 作者单位： | 福建医科大学附属第一医院麻醉科,福州,35005 |
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| 摘 要： | 环氧化酶(COX)主要有COX-1和COX-2两种异构酶,前者是一种"管家酶",后者是一种可诱导酶。多种因素会调控COX基因表达。机体受到伤害性刺激后,外周和中枢COX异构酶表达均发生变化,激活COX-PG级联反应,产生具有重要功能的PG类物质,PG与相应受体相结合,调控痛觉过敏。非甾体类药物通过外周和中枢双重抑制COX异构酶,通过改变前列腺素类物质的量,发挥抗伤害效应。
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| 关 键 词： | 环氧化酶 非甾体类药物 抗伤害效应 痛觉过敏 |
The Role of Cyclooxygenase in Antinociceptive Effects of Non-steroidal Anti-inflammatory Drug |
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| LU Guo-Lin,LIN Cai-zhu. The Role of Cyclooxygenase in Antinociceptive Effects of Non-steroidal Anti-inflammatory Drug[J]. Medical Recapitulate, 2008, 14(13): 2039-2041 |
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| Authors: | LU Guo-Lin LIN Cai-zhu |
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| Affiliation: | LU Guo-Lin,LIN Cai-zhu.(Department of Anesthesiology,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China.) |
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| Abstract: | The cyclooxygenase (COX) has two types of isomerase,ie.COX-1 and COX-2.COX-1 is a housekeeper enzyme and COX-2 is an inducible enzyme.Multiple factors regulate the expression of COX gene.After nociceptive stimulus imposing on the organism,the expression of both two isoforms varies in the peripheral and central nervous system activating the COX-PG cascade reaction,which induce a series of prostaglandins (PGs) with many important fuctions.PGs regulate organic hyperalgesia by combination with the homologous re... |
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| Keywords: | Cyclooxygenase Nonsteroidal anti-inflamatory drugs Aantinoci-captive effect Hyperalgesia |
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