骨纤维异样增殖症骨痛的治疗药物研究进展

骨纤维异样增殖症(FD)是一种先天性、非遗传性的类肿瘤疾病。在FD患者中骨痛非常普遍,但骨痛的发生机制仍然不明。目前没有理想的药物能够彻底根治骨痛。现阶段的治疗药物主要包括非甾体药物、麻醉性止痛药和二膦酸盐类药物如帕米膦酸二钠、唑来膦酸盐、阿仑膦酸钠、托珠单抗和地诺塞麦,主要对上述FD骨痛的治疗药物进行综述。

Research progress on therapeutic drugs for treatment of fibrous dysplasia patients with bone pain

Fibrous dysplasia (FD) is a congenital and nonheritable genetic disorder characterized by tumor-like disease. Bone pain is common in FD patients, but the mechanism is still unknown. There are no ideal drugs to cure pain of FD thoroughly. Until now, therapeutic drugs for treatment of fibrous dysplasia patients with bone pain include non steroid anti inflammatory drug, narcotic analgesics, and bisphosphonates such pamidronate disodium, zoledronate, alendronate sodium, astocilizumab, and denosumab. Research progress on those therapeutic drugs for treatment of fibrous dysplasia patients with bone pain are reviewed in this paper.