| 颅脑损伤大鼠肠道防御素-5 mRNA表达 |
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| 引用本文： | 赵希敏,刘霞.颅脑损伤大鼠肠道防御素-5 mRNA表达[J].临床神经外科杂志,2007,4(1):1-3. |
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| 作者姓名： | 赵希敏 刘霞 |
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| 作者单位： | 1. 201900,上海宝山中心医院神经外科
2. 上海宝山中心医院麻醉科 |
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| 基金项目： | 上海市科委科研基金资助项目（034119942） |
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| 摘 要： | 目的探讨弥漫性脑损伤后肠道防御素-5（RD-5）变化。方法大鼠32只，分为对照组8只；弥漫性脑损伤组24只，再分成3个亚组（24h，3d，7d）。观察回肠RD-5mRNA的表达，回肠肠粘膜的病理改变以及血液内毒素的变化。结果弥漫性脑损伤后24hRD-5 mRNA的表达显著升高（P〈0．01），伤后3d降低至正常水平以下；回肠肠粘膜损伤，血液内毒素伤后24h最高（P〈0．01），3至7d仍显著高于正常水平（P〈0．01）。结论弥漫性脑损伤早期RD-5 mRNA的表达增强可能是机体的一种保护性反应。
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| 关 键 词： | 防御素-5 弥漫性脑损伤 内毒素 大鼠 |
| 文章编号： | 1672-7770（2007）01-0001-03 |
| 收稿时间： | 2006-10-29 |
| 修稿时间： | 2006-12-08 |
Expression of rat defensin-5 mRNA in rat intestine following diffuse brain injury |
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| ZHAO Xi-min,LIU Xia.Expression of rat defensin-5 mRNA in rat intestine following diffuse brain injury[J].Journal of Clinical Neurosurgery,2007,4(1):1-3. |
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| Authors: | ZHAO Xi-min LIU Xia |
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| Abstract: | Objective To investigate the expression changes of rat defensin-5(RD-5) following diffuse brain injury. Methods 32 SD rats were divided randomly into control group(n=8)and diffuse brain injury groups which include 24 h(n=8),3 d(n=8) and 7 d(n=8) subgroup.The expression of RD-5 in rat intestine was determined with RT-PCR.Pathological changes of intestines and endotoxin in vein blood were investigated.Results RD-5 mRNA expression in rat intestine increased significantly after diffused brain injury at 24 h(P<0.01),and decreased to a level lower than control at 3 d. Intestinal mucosal was injured. The endotoxin of vein blood in diffuse brain injury group from 24 h to 7 d was higher than that in the control group.Conclusions The increased expression of RD-5 mRNA in the early stage after the brain injury might be a host protective response. |
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| Keywords: | defensin-5 diffuse brain injury endotoxin rat |
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