乙型肝炎血源疫苗与卡介苗的联合应用

本文观察HBsAg阳性孕妇77例,其新生儿生后当天接种乙肝疫苗,次日接种卡介苗;同期HBsAg阴性孕妇的新生儿8,289例,单接种卡介苗。3个月时结核菌素试验阳转率分别为92.2％、93.4％。卡介苗在乙肝疫苗后接种无干扰作用。

ADMINISTRATION OF HEPATITIS B PLASMA VACCINE IN COMBINATION WITH BCG

77 newborns of HBsAg positive carried mothers were immunized with hepatitis B plasma vaccine within 24 hours after delivery and with BCG on the next day.The positive rate of tuberculin test in these babies at 3 months of age was 92.2% as compared to 93.4% in 8289 babies of non-carried mothers to whom BCG alone was given.The hepatitis B vaccine did not seem to interfere the immunogenicity of BCG.The protective efficacy of the hepatitis B vaccine for preventing perinatal transmission of hepatitis B virus in the babies of carried mothers,when used in combination with BCG,ranged between 67-89% The protective efficacy of hepatitis B vaccine for babies of carried mothers,when used alone,was estimated to be 71-74%,as it was reported elsewhere.Thus,the use of BCG did not interfere the immunogenicity of hepatitis B vaccine.