Ectopic prolactin secretion from a gonadoblastoma |
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Authors: | W H Hoffman R R Gala K Kovacs M G Subramanian |
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Institution: | Medical College of Georgia, Augusta 30912-3770. |
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Abstract: | A 6.5-year-old girl developed isosexual, pseudoprecocious puberty secondary to a gonadoblastoma. The tumor was found to produce and secrete both immunoassayable and bioassayable prolactin based on immunohistochemical techniques and the presence of a prolactin gradient between the tumor vein and peripheral vein. The source of the prolactin was a Sertoli-like cell. Neither growth hormone nor growth hormone-releasing hormone was detected within the tumor. This case confirms the ectopic production of prolactin by neoplastic tissue. |
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