Pulsed excimer laser angioplasty of human cadaveric arteries |
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| Authors: | E M Farrell L A Higginson W S Nip V M Walley W J Keon |
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| Affiliation: | 1. Gastroenterology and Hepatology, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, the Netherlands;2. Gastroenterology, Erasme UnCiversity Hospital, Brussels, Belgium;3. Institute of Diabetes, Endocrinology, and Obesity, King’s Health Partners, London, UK;4. Department of Endocrinology, Erasme University Hospital, Brussels, Belgium;5. Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands;6. Bariatric Endoscopy Service, Gastro Obeso Center, Sao Paulo, Brazil;7. CCO Clinical Center for Diabetes, Obesity and Reflux, Santiago, Chile;8. Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy;9. Department of Diabetes, School of Life Course Sciences, King’s College London, London, UK;10. Università Cattolica del Sacro Cuore, Rome, Italy;11. Internal and Vascular Medicine, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands;12. Internal Medicine, Fondazione Policlinico A. Gemelli IRCSS, Rome, Italy;13. Department of Gastroenterology, University College Hospital, London, UK;14. Center for Obesity Research, Department of Medicine, University College London, London, UK;15. Fractyl Laboratories Inc, Lexington, MA, USA;1. Department of Computer Science Engineering, Sona College of Technology, Salem, 636005, Tamilnadu, India;2. School of Information Technology and Engineering, VIT University, Vellore, 632014, Tamilnadu, India;3. Department of Electrical and Communication Engineering, The PNG University of Technology, Lae, Papua New Guinea;4. Department of Information Technology, VNR Vignana Jyothi Institute of Engineering & Technology, India;5. Department of Computer Science and Computer Engineering, La Trobe University, Melbourne, Australia;1. Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran 14399-57131, Iran;2. Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417614335, Iran;3. UT and TUMS Cancer Electronics Research Center, Tehran University of Medical Sciences, Tehran, Iran;4. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX 15179/64311, Tehran, Iran;5. Department of Surgery and Radiology, Faculty of Veterinary Medicine, University of Tehran, P.O. BOX 14155/6453, Tehran, Iran;6. Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran;7. SEPAS pathology Lab, P.O.BOX 1991945391, Tehran, Iran;8. Cancer Institute, Imam-Khomeini Hospital, Tehran University of Medical Sciences, P.O. BOX 13145-158, Tehran, Iran;1. Department of Surgery, University of Genoa, Genoa, Italy;2. Department of Internal Medicine, University of Genoa, Genoa, Italy;3. Bariatric Surgery Unit, IRCCS Humanitas Research Hospital, Milan, Italy;1. Mechanobiology & Biomaterials Group, CIRMAP, Research Institute for Biosciences, University of Mons, B-7000, Mons, Belgium;2. Neuroscience Laboratory, Neuroscience Department, Research Institute for Biosciences, University of Mons, B-7000, Mons, Belgium;3. Neurophysiology Laboratory, BIOMED Research Institute, UHasselt, B-3500, Hasselt, Belgium;4. Univ. Lille, Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, F-59000, Lille, France;5. Univ. Grenoble Alpes, Inserm, U1216, CHU Grenoble Alpes, Grenoble Institut Neuroscience, F-38000, Grenoble, France |
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| Abstract: | Laser angioplasty has been limited by the lack of precise control of thermal and acoustic vascular injury. Pulsed excimer lasers, by contrast, have a capacity to affect target tissue without heat dispersion or damage to surrounding structures. The ablative properties of three excimer wavelengths, krypton fluoride (249 nm), xenon chloride (308 nm), and xenon fluoride (351 nm), were investigated with the use of fresh human cadaveric normal and atherosclerotic femoral arteries. Light and electron microscopy demonstrated clean cuts with histologically normal edges. There was no evidence of either thermal or acoustic damage with any of the wavelengths studied. The depth of ablation varied directly with the number of pulses and inversely with tissue density while the incision width remained constant. The excimer laser appears to offer significant advantages over its conventional counterparts for the ablation of atherosclerotic plaque. |
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