The Relationship between pKa and Skin Irritation for a Series of Basic Penetrants in Man |
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| Authors: | BERNER BRET; WILSON DONALD R; STEFFENS ROBERT J; MAZZENGA GERARD C; HINZ ROBERT; GUY RICHARD H; MAIBACH HOWARD I |
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| Institution: | *CIBA-GEIGY Corporation 444 Saw Mill River Road, Ardsley, New York 10502
 CYGNUS 701 Galveston Drive, Redwood City, California 94063
 University of California, Departments of Pharmacy and Pharmaceutical Chemistry San Francisco, California 94143
 University of California Medical School, Department of Dermatology San Francisco, California 94143
Received August 4, 1989;
accepted July 6, 1990 |
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| Abstract: | The Relationship between pKa and Skin Irritation for a Seriesof Basic Penetrants in Man. BERNER, B., WILSON, D. R., STEFFENS,R. J., MAZZENGA, G. C., HINZ, R., GUY, R. H., AND MAIBACH, H.I. (1990). Fundam. Appl. Toxicol 15, 760–766. For a seriesof bases, which penetrate through human skin in vitro at similarrates (0.056–0.49 µM/cm²/hr), penetrant pKais shown to correlate with erythema, edema, and color meterreadings. As estimates of irritation, erythema, edema, and rednessmeasurements are highly linearly correlated. For the selectedseries, irritation becomes significant for bases with a pKa> 8. The irritation potential of acids with pKa  4 has beenpreviously reported; pKa appears highly predictive of acuteskin irritation for acids and bases in man. |
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