Allochronic Overlapping Malignancies After Renal Transplantation in a Patient with p53 Gene Mutation: Report of a Case |
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Authors: | Teruhiko Kitayama Seiji Marubayashi Keisuke Hayamizu Hirotaka Tashiro Hideki Ohdan Satoshi Ikeda Tatsuya Okimoto Masazumi Okajima Tuyoshi Kataoka Keizo Sugino Toshimasa Asahara Yasuhiko Fukuda Kiyohiko Dohi |
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Affiliation: | (1) Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan;(2) Department of Blood Purification, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan;(3) Department of Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan |
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Abstract: | We report a rare case of the development of various tumors over a 16-year period after renal transplantation. A 56-year-old woman underwent renal transplantation using a US kidney. Immunosuppressive treatment consisted of a triple regimen of methylprednisolone, azathioprine, and mizoribine. Left breast cancer was diagnosed 9 years after the renal transplantation, then colon cancers and meningeal epidermal meningioma were diagnosed, 10 years and 12 years post-transplant, respectively. During the investigations for the breast and colon cancers, a p53 gene mutation was detected. A deterioration of renal function was found 16 years after the transplant and graft biopsy confirmed chronic rejection. We suggest that the effects of the immunosuppressive drugs combined with the p53 gene abnormality accelerated tumor development in this patient. |
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Keywords: | Renal transplantation Allochronic overlapping tumor p53 gene mutation Immunosuppression |
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