| 非甾体抗炎药洛索洛芬钠的合成改进 |
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| 引用本文： | 唐文生,潘丽坤,孙平华,孙铁民.非甾体抗炎药洛索洛芬钠的合成改进[J].中国药物化学杂志,2002,12(5):292-294. |
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| 作者姓名： | 唐文生 潘丽坤 孙平华 孙铁民 |
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| 作者单位： | 1. 沈阳药科大学制药工程学院,辽宁,沈阳,110016
2. 鞍山市第四人民医院,辽宁,鞍山,114034 |
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| 摘 要： | 洛索洛芬钠是一种副作用小、疗效高的非甾体类抗炎镇痛药。在总结前人工作的基础上，对其合成工艺中的重要中间体2-（-4-氯甲基苯基）丙酸乙酯的合成进行了改进，以催化剂四氯化钛替代四氯化锡，取得了很好的效果，总收率为58%（原文献收率为36%）。
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| 关 键 词： | 非甾体抗炎药 洛索洛芬钠 合成 |
| 文章编号： | 1005-0108(2002)05-0292-03 |
Synthesis of a non-steroid anti-inflammatory drug loxoprofen sodium |
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| TANG Wen sheng ,PAN Li kun ,SUN Ping hua ,SUN Tie min.Synthesis of a non-steroid anti-inflammatory drug loxoprofen sodium[J].Chinese Journal of Medicinal Chemistry,2002,12(5):292-294. |
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| Authors: | TANG Wen sheng PAN Li kun SUN Ping hua SUN Tie min |
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| Institution: | TANG Wen sheng 1,PAN Li kun 2,SUN Ping hua 1,SUN Tie min 1 |
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| Abstract: | Loxoprofen sodium is a kind of a non steroid anti inflammatory and antalgic drug with less side effects and high effect.In this article,the synthesis of the most important intermediate ethyl p (chloromethyl)phenyl]propionate in the synthetic route of loxoprofen sodium was improved based on the previous research.The catalyst TiCl 4 instead of SnCl 4 was used in the experiments,and a wonderful result was obtained.The overall yield was increased from 36% to 58%. |
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| Keywords: | steroid anti inflammatory loxoprofen sodium synthesis |
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