| 禁用药物β_2-激动剂的分析研究 |
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| 引用本文： | 朱绍棠,徐友宣,张建丽.禁用药物β_2-激动剂的分析研究[J].中国运动医学杂志,2003,22(5):479-482. |
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| 作者姓名： | 朱绍棠 徐友宣 张建丽 |
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| 作者单位： | 国家体育总局运动医学研究所兴奋剂检测中心,北京,100029 |
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| 摘 要： | 采用灵敏度很高的气相色谱 /负离子化学电离质谱 (GC/NICIMS)对 9种国际奥委会禁用药物 β2 -激动剂进行分析研究 ,比较了不同衍生化方法得到的产物在NICIMS上的响应。确定了五氟丙酸酐衍生化产物有最佳的灵敏度 ,适合此类药物的检测要求。重点对克伦特罗尿样进行了检测 ,其结果符合实际工作的需要
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| 关 键 词： | β2-激动剂 GC/MS NICIMS |
| 修稿时间： | 2003年8月14日 |
Researches on the Analysis of β2-Agonists by Using GC/NCI/MS |
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| Zhu Shaotang,Xu youxuan,Zhang Jianli China Doping Control Centre,National Research Institute of Sports Medicine,Beijing.Researches on the Analysis of β2-Agonists by Using GC/NCI/MS[J].Chinese Journal of Sports Medicine,2003,22(5):479-482. |
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| Authors: | Zhu Shaotang Xu youxuan Zhang Jianli China Doping Control Centre National Research Institute of Sports Medicine Beijing |
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| Institution: | Zhu Shaotang,Xu youxuan,Zhang Jianli China Doping Control Centre,National Research Institute of Sports Medicine,Beijing,100029 |
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| Abstract: | Nine β 2-Agonists banned by International Olympic Committee were studied in this paper. Three kinds of derivatizing methods were compared for the purpose of GC/MS analysis with Negative Ion Chemical Ionization. Pentafluoropropionic anhydride (PFPA) was shown to be the best regent for the NCI analysis. Clenbuterol (CLE) positive urine was analyzed by comparing the selected ion monitoring of blank urine, spiked urine and positive urine. |
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| Keywords: | GC/MS NICIMS |
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