2型糖尿病视网膜病变相关因素的有序Logistic回归分析

目的:分析2型糖尿病(T2DM)患者糖尿病视网膜病变(DR)相关危险因素,为糖尿病视网膜病变的防治提供依据。方法:选择T2DM患者200例,根据DR分期分为三组,比较各组临床资料的差异,并纳入有序Logistic回归,分析DR的危险因素。结果:经有序Logistic回归分析,空腹C肽OR值为0.641,说明空腹C肽值每增加1ng/ml,DR严重程度下降35.9%。病程在5～9年的患者DR的严重程度是病程<5年的患者的2.95倍;病程≥10年的患者DR的严重程度是病程5～9年的患者的2.90倍。UAER 20～199μg/min组患者DR严重程度是UAER<20μg/min组的7.69倍;UAER≥200μg/min组患者DR严重程度是UAER 20～199μg/min组的2.07倍。结论:空腹C肽是2型糖尿病患者视网膜病变的一个保护因素;糖尿病病程、UAER是其独立危险因素。保护胰岛β细胞功能,维持一定的空腹C肽水平,可以延缓糖尿病视网膜病变的进展。

Ordinal Logistic Regression Analysis of Relevant Factors on Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus

Objective:To analyze the related risk factors of diabetic retinopathy(DR) in patients with type 2 diabetes mellitus(T2DM).Methods:200 patients with type 2 diabetes mellitus were divided into three groups according to the classification of DR.The clinical date were collected and analyzed by ordinal logistic regression.Results:The OR of fasting plasma C-peptide was 0.641 by ordinal logistic regression,it suggested that when the fasting plasma C-peptide increased 1ng/ml,the severity of DR decreased 35.9%.The severity of DR with the group in 5~9 years course was 2.95 times that of the group of the course <5 years.The severity of DR with the group of the course≥10 years was 2.90 times that of the group in 5~9 years course.The severity of DR in patients with UAER 20~199μg/min was 7.69 times that of the patients with UAER<20μg/min.The severity of DR in patients with UAER≥200μg/min was 2.07 times that of the patients with UAER 20~199μg/min.Conclusion: The fasting plasma C-peptide was one protective factor of DR.The diabetic course and UAER were independent risk factors of DR.A certain level of fasting plasma C-peptide should be retained in the treatment of patients with T2DM to retard the progression of DR.