新生儿应激性高血糖血清脂联素检测156例

目的:探讨应激性高血糖新生儿血清脂联素的变化。方法:采用ELISA法对156例应激性高血糖患儿(观察组)及45例健康的新生儿(对照组)血清脂联素进行动态的检测,并对检测结果进行分析。结果:(1)应激性高血糖新生儿急性期血清脂联素的水平明显低于正常对照组,差异有统计学意义(P<0.05)。(2)应激性高血糖组新生儿血糖恢复期血清脂联素的水平明显回升接近正常对照组,差异无统计学意义(P>0.05)。(3)血糖水平越高血清脂联素的水平下降愈明显,差异有统计学意义(P<0.05)。(4)应激性高血糖死亡新生儿血清脂联素水平显著低于存活的新生儿,差异有统计学意义(P<0.01)。结论:应激性高血糖新生儿血清脂联素的水平随着血糖水平的升高而下降,并且随病情的严重程度加重而降低,血清脂联素是应激性高血糖发生的重要因素之一,亦是导致危重新生儿死亡的重要因素之一,对应激性高血糖危重新生儿病情诊治和预后判断有指导意义。

Clinical Significance of Serum Adiponectin for 156 Cases of Neonates with Stress Hyperglycemia

Objective:To explore serum adiponectin changes in neonates with stress hyperglycemia.Methods:Enzyme-linked immunoabsorbent assay was used to detect the serum adiponectin in 156 neonatal stress hyperglycemia(the observation group) and 45 cases of neonatal health(control group),and the detection results by stastistic analysis.Results:The serum adiponectin levels of neonates with Stress hyperglycemia in the acute phase was significantly lower than the normal control group,the difference was statistically significant(P<0.05).The serum adiponectin levels of neonates with Stress hyperglycemia in the recovery phase was not significantly difference than the normal control group,the difference was not statistically significant(P>0.05).The serum adiponectin levels of higher blood sugar level neonates with Stress hyperglycemia was significantly lower than that of lower blood sugar levels.The serum adiponectin levels of death neonates with Stress hyperglycemia was significantly lower than that of survival,the difference was statistically significant(P<0.01).Conclusion::The serum adiponectin levels of neonates with Stress hyperglycemia was inverse ratio with the blood sugar levels and also with the severity of the illness.Serum adiponictin involved in hyperglycemia and also one of the important death factors.It had clinical significance for diagnosis and prognostic evaluation.