胎盘型钙黏蛋白在寻常性银屑病患者血清和皮损中的表达及意义

目的探讨胎盘型钙黏蛋白（P-cadherin，P-cad）在寻常性银屑病发病中的作用和意义。方法选择寻常性银屑病患者40例，分别采用酶联免疫吸附法和免疫组化法检测患者血清和皮损中P-cad的表达，另40名正常人作为对照。结果寻常性银肩病患者血清中P-cad表达水平明显高于正常对照者（P〈0.01），表达水平与病情严重程度呈正相关；寻常性银屑病患者皮损中P-cad在角质形成细胞（keratinocyte，KC）各层均有表达，而正常对照组仅在表皮基底层表达，表达水平差异有统计学意义，且与银屑病皮损严重程度指数（PASI）呈正相关。结论P-cad在寻常性银屑病呈高表达，且与疾病严重程度呈正相关。

Expression and significance of P-cad in patients with psoriasis vulgaris

Objective To explore the role of P-cad in the pathogenesis of psoriasis vulgaris. Methods Venous blood was collected from 40 healthy control and 40 patients with psoriasis vulgaris. The serum P-cad was detected by ELISA. The expression of P-cad in skin lesion was analyzed by immunohistochemical staining. Results Expression level of P-cad in psoriasis vulgaris serums was significantly higher than in normal controls (P<0.01), expression level relates to severity of illness, which was a positive correlation. Expression strong of P-cad in skin lesions of psoriasis vulgaris while healthy control group was just expressed in basal layer of epidermis. Conclusion Expression level of P-cad in psoriasis vulgaris was significantly higher than in normal controls, expression level relates to severity of illness, which was a positive correlation.