缬沙坦治疗早期糖尿病肾病的临床观察

目的观察缬沙坦治疗早期糖尿病肾病的临床疗效。方法选取60例早期糖尿病肾病患者,随机分为2组。对照组30例,单纯给予糖尿病综合治疗;治疗组30例,在对照组基础上加用缬沙坦80mg/d治疗。疗程为8周。观察其治疗前后尿白蛋白排泄率和肾功能变化,记录不良反应。结果治疗后2组UAER经统计学比较,差异有统计学意义（P〈0.05）;治疗后2组BUN、Scr未增高,经统计学比较,无统计学差异（P〉0.05）。结论缬沙坦能有效降低尿蛋白,保护肾功能,临床应用安全。

Clinical Observe on Early Treatment of Diabetic Nephropathy with Valsartan

Objective To observe the effect of valsartan in treatment of early clinical diabetic nephropathy.Methods 60 patients with early diabetic nephropathy patients were randomly divided into 2 groups.The control group of 30 patients given a comprehensive treatment of diabetes;treatment group 30 cases in the control group was added based on valsartan 80 mg/d treatment.Treatment for 8 weeks.Observed before and after treatment of urinary albumin excretion rate and renal function changes,record adverse reactions.Results After treatment,UAER by the two groups statistically,the difference was statistically significant（P0.05）;two BUN,Scr is not increased after treatment,no statistically significant difference（P0.05）.Conclusion Valsartan can effectively reduce urinary protein,protecting renal function and clinical application security.