Selective depletion of the OKT 4+ 4B4+ subset in lymph nodes from HIV+ patients |
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Authors: | P De Paoli A Carbone S Battistin M Crovatto N Arreghini G Santini |
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Affiliation: | Servizio di Microbiologia-Immunologia, Ospedale Civile, Pordenone, Italy. |
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Abstract: | We have used 4B4 and 2H4 monoclonal antibodies in conjunction with OKT 4 to quantify T cell subsets in lymph node suspensions from human immunodeficiency virus (HIV) positive subjects with lymphadenopathy syndrome. The data indicate that the reduced OKT 4:OKT 8 ratio was due to a depletion of the OKT 4+ 4B4+ subset. In contrast, there were no differences compared to reactive controls, considering the OKT8+ subpopulation. These alterations may be related to the immunological deficiency associated with HIV infection. |
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