复合造模因素诱导脾虚水湿不化模型大鼠胃肠功能的改变

目的: 研究脾虚水湿不化模型大鼠在胃肠功能方面的改变。方法:将40只大鼠随机分为空白对照组和模型组,每组20只。空白对照组大鼠给予纯化饲料喂养;模型组大鼠给予高脂低蛋白饲料喂养,同时负重力竭游泳,连续喂养60 d。观察大鼠的一般状况,检测大鼠血清淀粉酶含量,血清胃泌素含量及尿D-木糖的排泄率。结果:与空白对照组相对比,模型组大鼠血清淀粉酶含量,血清胃泌素含量及尿D-木糖的排泄率均有降低的趋势(P<0.05),具有显著性差异。结论: 脾虚水湿不化模型大鼠会出现胃肠功能的减退。

Changes in Gastrointestinal Functions of Rat Model with Dampness Stagnancy due to Spleen Deficiency Induced by Compound Molding Factors

Objective：To explore changes in gastrointestinal functions of rat model with dampness stagnancy due to spleen defi- ciency. Methods ：40 rats were divided into the control group and model group,20 in each. Rats in control group were given purifi- cation feed while rats in model group were given high - fat and low - protein feed, and daily loaded swimming until exhausted for totally 60 days. We observed rats＇ conditions and test serum amylase content,serum gastrin levels and excretion rate of D -xylose in urine. Results ： Compared with the control group, serum amylase content, serum gastrin levels and excretion rate of D - xylose in urine of rats in model group tended to decrease with significant differences（ P 〈 O. 05 ）. Conclusion：Rat model with dampness stagnancy due to spleen deficiency has gastrointestinal hypofunction.