| 大鼠脊髓急性损伤后内皮素-1含量的变化 |
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| 引用本文： | 鲁凯伍,侯铁胜,傅强,李明,赵杰,栗景峰. 大鼠脊髓急性损伤后内皮素-1含量的变化[J]. 第二军医大学学报, 2001, 22(10): 932-934 |
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| 作者姓名： | 鲁凯伍 侯铁胜 傅强 李明 赵杰 栗景峰 |
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| 作者单位： | 第二军医大学长海医院骨科 |
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| 基金项目： | 上海市科委带头人基金资助项目 ( 97XD14 0 15 |
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| 摘 要： | 目的：通过检测大鼠脊髓急性损伤后内皮素－1（ET－1）的含量变化，探讨ET－1在脊髓继发性损伤中可能的作用机制。方法：用35g负荷压迫大鼠胸段脊髓（T8－9）5min，造成大鼠胸段脊髓急性损伤，用放射免疫法测定大鼠脊髓急性损伤后早期血浆和伤段脊髓组织中ET－1的含量。结果：脊髓损伤后30min，血浆，伤段脊髓组织中ET－1水平显升高，4h达最高峰，并分别持续至48h和72h。结论：ET－31参与脊髓继发性损伤，可能是伤后4－24h重要的损害因子之一。
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| 关 键 词： | 内皮缩血管肽类 脊髓损伤 |
| 文章编号： | 0258-879(2001)10-0932-03 |
| 修稿时间： | 2001-05-18 |
Changes of endothelin-1 levels in acute spinal cord injury in rats |
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| LU Kai Wu,HOU Tie Sheng,FU Qiang,LI Ming,ZHAO Jie,LI Jing Feng. Changes of endothelin-1 levels in acute spinal cord injury in rats[J]. Former Academic Journal of Second Military Medical University, 2001, 22(10): 932-934 |
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| Authors: | LU Kai Wu HOU Tie Sheng FU Qiang LI Ming ZHAO Jie LI Jing Feng |
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| Abstract: | Objective:To explore the possible role of endothelin 1(ET 1) in secondary spinal cord injury (SCI) by measuring the changes of ET 1 levels after SCI in rats. Methods:The thoracic spinal cord of rats was compressed by a load of 35 g for 5 min, causing a moderate injury. The changes of ET 1 levels in plasma and injured spinal cord tissues were examined by means of radioimmunoassay. Results:ET 1 concentrations in plasma and injured tissues were significantly increased 30 min after spinal cord compression and reached its peak at 4 h, then it restored slowly to normal level in 72 h. Conclusion:ET 1 contributes to the pathophysiological actions of secondary SCI, it may play a key role in secondary injury at 4 24 h after acute SCI. |
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| Keywords: | endothelins spinal cord injuries |
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