| 慢性应激抑郁模型大鼠海马突触素及多巴胺转运体mRNA表达的初步研究 |
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| 引用本文： | 宋炜熙,胡随瑜.慢性应激抑郁模型大鼠海马突触素及多巴胺转运体mRNA表达的初步研究[J].中华行为医学与脑科学杂志,2009,18(7). |
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| 作者姓名： | 宋炜熙 胡随瑜 |
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| 作者单位： | 1. 湖南中医药大学中西医结合学院,长沙,410208
2. 中南大学湘雅医院中西医结合研究所 |
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| 基金项目： | 湖南省教育厅资助项目 |
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| 摘 要： | 目的 观测抑郁模型大鼠海马突触素、多巴胺转运体mRNA的表达,探讨抑郁症的发病机制.方法 采用慢性应激复制抑郁大鼠模型.将20只大鼠随机分为正常组、抑郁模型组,以RT-PCR法研究抑郁模型大鼠海马突触素、多巴胺转运体mRNA的表达.结果 正常组海马突触素、多巴胺转运体mRNA的平均光密度值分别为0.84±0.08和1.24±0.08;模型组两者的平均光密度值1.24±0.12和1.85±0.09,2组比较差异有统计学意义(t值分别为8.87和16.50,P<0.01).结论 抑郁模型大鼠海马突触素、多巴胺转运体mRNA表达较正常大鼠显著增加.
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| 关 键 词： | 抑郁症 大鼠 海马 突触素 多巴胺转运体 |
Expression of synapsin and dopamine transporter mRNA in hippocampus of chronic stress depression model rats |
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| Authors: | SONG Wei-xi HU Sui-yu |
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| Abstract: | Objective To study the mechanism of depression by explore the expressional differences of synapsin and dopamine transporter(DAT) mRNA of hippocampus in depression model rats. Methods Depression model were replicated by chronic stress. 20 rats were randomly divided into normal control group(n=10) and de-pression model group(n=10). Synapsin and DAT mRNA expressions in hippocampns were detected with RT-PCR technique. Result The values of synapsin and DAT mRNA in hippocampus of normal control group were 0.84±0.08 and 1.24±0.08, respectively, and 1.24±0.12 and 1.85±0.09 of model group, their t values were 8.87 and 16.50 (P<0.01). Conclusion The expressions of synapsin and DAT mRNA in hippecampus of depression model rats were increased significantly. |
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| Keywords: | Depression Rats Hippocampus Synapsin Dopamine transporter |
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