摘 要: | Liver fibrosis is a gradual process of increasedsecretion and decreased degradation of extracellularmaterials(ECM).Most author hold that the process isinitiated by the damage of hepatic cells(HCs),whichleads to activation and secretion of multiple cellularfactors of Kupffer cells.These factors,along with thecellular factors secreted by damaged HCs,thrombocytes and endothelial cells of the hepaticsinusoid,and some chemical mediators are activators
|