Lehualides A-D, metabolites from a Hawaiian sponge of the genus Plakortis |
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| Authors: | Sata Noriko Abinsay Hazel Yoshida Wesley Y Horgen F David Sitachitta Namthip Kelly Michelle Scheuer Paul J |
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| Affiliation: | Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA. |
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| Abstract: | A collection of an undescribed marine sponge of the genus Plakortis yielded four new "polyketide-derived" metabolites, lehualides A-D (1-4). The structures of compounds 1-4 were elucidated by interpretation of spectral data. Compound 2 demonstrated cytotoxicity against an ovarian cancer cell line, while compound 4 was active against both ovarian cancer and leukemia cell lines. |
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