线粒体ATP敏感的钾通道和缺血再灌注损伤

细胞上存在两种ATP敏感的钾通道，一是位于细胞膜上的ATP敏感的钾通道；二是位于线粒体膜上的ATP敏感的钾通道。最近的药理学和分子生物学研究认为线粒体ATP敏感的钾通道开放对器官缺血再灌注损伤有保护作用。这些研究表明线粒体ATP敏感的钾通道在器官保护中具有关键作用。本文介绍了线粒体ATP敏感钾通道的结构和生理学特性，线粒体在缺血再灌注损伤中的生理变化及可能的机制，还有在器官保护中的研究进展。

Mitochondrial KATP channel and ischemia reperfusion injury

Two distinct ATP-sensitive K channels have been described in cell: sarcolemmal KATP channel and mitochondrial KATP channel.Recent pharmacologic and molecular biology studies suggest the activation of mitochondrial KATP channel as relevant organ protective site after ischemia reperfusion.These findings indicate a central role for mitochondrial KATP channel in organ protection.This review describes the characteristics of mitochondrial KATP channel,physiological consequences and possible mechanisms of this channel,and latest progress in organ protection.