| 受体酪氨酸蛋白激酶的研究 |
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| 引用本文： | 曹川,戴霞,李世荣. 受体酪氨酸蛋白激酶的研究[J]. 医学综述, 2008, 14(12): 1780-1781 |
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| 作者姓名： | 曹川 戴霞 李世荣 |
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| 作者单位： | 中国人民解放军第三军医大学附属西南医院整形外科,重庆,400038 |
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| 摘 要： | 酪氨酸蛋白激酶是细胞信号转导的主要信号酶之一，对细胞的生长、发育与功能调控起着重要的作用。受体型酪氨酸蛋白激酶是细胞内段具有酪氨酸激酶活性跨膜结构的酶蛋白受体，其胞外区与生长因子配体结合，然后激活胞内段的酶活性区启动信号转导，参与细胞的生长、增殖、转化及胚胎发育和肿瘤形成。主要介绍受体型酪氨酸蛋白激酶的结构、分类及其信号转导途径。
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| 关 键 词： | 受体酪氨酸蛋白激酶 信号转导 丝裂原活化蛋白激酶 |
| 文章编号： | 1006-2084(2008)12-1780-02 |
| 修稿时间： | 2007-12-20 |
Research Progress of Receptor Tyrosine Protein Kinase |
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| CAO Chuan,DAI Xia,LI Shi-rong. Research Progress of Receptor Tyrosine Protein Kinase[J]. Medical Recapitulate, 2008, 14(12): 1780-1781 |
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| Authors: | CAO Chuan DAI Xia LI Shi-rong |
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| Affiliation: | CAO Chuan,DAI Xia,LI Shi-rong.(Department of Plastic Surgery,Southwestern Hospital,Third Military Medical University of PLA,Chongqing 400038,China) |
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| Abstract: | Tyrosine protein kinase is one of the key kinases in cell signal transduction,which plays an important role in cell growth,development and functional regulation.Receptor tyrosine protein kinase is a transmembrane kinase protein receptor with tyrosine protein kinase activity on intracellular part,it can actuate the signal transduction by activating the active zone of its intracellular part resulting from the combination of its extrocellular part with its growth factor ligand and then takes part in the cell g... |
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| Keywords: | Receptor tyrosine protein kinase Signal transduction Mitogen activited protein kinase |
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