Th17和FOXP3+T在胃黏膜相关淋巴组织淋巴瘤发病中的意义

  目的  探讨Th17和FOXP3+T（Treg）阳性细胞在慢性胃炎、淋巴细胞性胃炎和胃黏膜相关淋巴组织（MALT）淋巴瘤中的意义。  方法  采用免疫组织化学方法检测18例慢性胃炎、17例淋巴细胞性胃炎和18例低度恶性胃MALT淋巴瘤组织中Th17及FOXP3+T细胞的表达情况。  结果  Th17在慢性胃炎组、淋巴细胞性胃炎组和胃MALT淋巴瘤组阳性细胞数分别为（11.2±2.4）、（15.1±5.3）和（16.8±5.4）个/每高倍镜视野，胃MALT淋巴瘤与慢性胃炎相比，差别有统计学意义（P < 0.05），但胃MALT淋巴瘤与淋巴细胞性胃炎间差别无统计学意义（P>0.05）。FOXP3+T在慢性胃炎组、淋巴细胞性胃炎组和胃MALT淋巴瘤组的细胞数分别为（5.1±2.7）、（22.4±4.0）和（30.8±7.2）个/每高倍镜视野，三组间两两比较差异均有统计学意义（P < 0.05）。FOXP3+T和Th17细胞数量改变在胃MALT淋巴瘤组呈正相关（R=0.308，P < 0.05）。  结论  FOXP3+T和Th17细胞数量在淋巴细胞性胃炎和胃MALT淋巴瘤组织中增多，可能在胃MALT淋巴瘤的发生、发展过程中发挥作用。 

Significance of Th17 and FOXP3+ Regulatory T Cells in Pathogenesis of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

  Objective  To investigate the role of Th17 and Treg in chronic gastritis, lymphocytic gastritis, and low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma.  Methods  The expression of FOXP3+Treg and Th17 in 18 chronic gastritis, 17 lymphocytic gastritis, and 18 gastric MALT lymphoma cases were detected by immunohistochemical staining.  Results  IL-17 expression increased in the chronic gastritis, lymphocytic gastritis, and gastric MALT lymphoma cases. However, no statistical significance was found in IL-17 expression between lymphocytic gastritis and gastric MALT lymphoma. The expression of FOXP3+Treg cells increased in the chronic gastritis, lymphocytic gastritis, and gastric MALT lymphoma cases (P < 0.05) (corresponding to 30.8 ± 7.2, 22.4 ± 4.0, and 5.1 ± 2.7 per high magnification field, respectively). The density of FOXP3+Treg cells was positively correlated with the expression of IL-17 (r = 0.308, P < 0.05).  Conclusion  Th17 and Treg may play certain roles in the development of gastric MALT lymphoma.