细胞因子诱导杀伤细胞治疗肾细胞癌的疗效观察

The effects of CIK cells on the treatment of renal cell carcinoma

Objective  To observe the effects of cytokine-induced killer (CIK) cells on the treatment of renal cell carcinoma. Methods  Twenty-eight postoperative cases with stage I or stage II renal cell carcinoma were admitted in our hospital from January 2002 to June 2006, all cases were pathologically confirmed, and were divided into group A (18 cases) and group B (10 cases). Group A was administrated 3–12 periods of CIK cells treatment combined with 5–7 cycles of IL-2 and INFα-2b, together with 4 cycles of chemotherapy (5-Fu + CF). Group B was given 4 cycles of chemotherapy (5-Fu + CF) and 5–7 cycles of IL-2 and INFα-2b. Results  Three cases in group A had metastatic masses in two lungs within 1 year and died within 2 years postoperatively. The other 15 cases are still alive and in good health. Six cases in group B had metastatic masses in two lungs or/and in abdominal cavity within 1 year, and 4 of them died within 2 years. All the 6 cases died within 3 years. The other 4 cases are still alive and in good health. Conclusion  CIK cells are safe and effective for the treatment of stage I or stage II renal cell carcinoma, which should be further widely used.