急性白血病患者辨证分型与血象、骨髓象及血、尿环核苷酸关系的临床观察

把59例急性白血病患者分为温毒瘀血、痰热症瘕、气阴两虚三型,观察其盘象、骨髓象和血、尿环核苷酸变化,发现各型与正常人比较均有显著差异,但程度并不一致。对32例患者治疗前后观察,气阴两虚型的缓解率较高,而温毒瘀血型较差。实验认为急白中医分型具有分子病理学基础。

Typology of Acute Leukemia According to Symptom Differentiation and Observation on Its Relation to Blood,Bone Marrow and Cyclic Nucleotides in Serum and Urine

Acute leukemia was classified into three types according to symptom differentiation:(1)Heat toxins with stagnant blood.(2)Aggregation of phlegm and heat;(3)Deficiency of beth Qi and Yin.The blood,bone marrow and cyclic nucteotides in serum and urine in the 59 patients were observed.The experiment has proved that all indices in each type are significantly different from that of the control,but present differences among one another.The hemoglobin and platelet were higher in aggregation of phlegm and heat than in other two types.The ratio of white cell/red cell of marrow was lower in deficiency of both Qi and Yin than in other two types.The cGMP in serum and urine were also reduced greatly than heat toxins with stagnant blood.However the ratio of cAMP/cGMP was higher than the first group.The change between pretreatment and post treatment in 32 patients was further observed.The percentage of remission was higher in deficiency of both Qi and Yin,but lower in heat toxins with stagnant blood.The experiment has indicated that the typology of acute leukemia into three types according to Chinese traditional medicine could serve as the base of molecular pathology.