DNA-hydrolyzing antibodies in lymphoproliferative diseases |
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| Authors: | A. V. Kozyr' A. V. Kolesnikov E. I. Yakhnina I. A. Astsaturov E. Yu. Varlamova E. V. Kirillov A. G. Gabibov |
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| Affiliation: | (1) Laboratory of the Chemical Bases of Biocatalysis, Institute of Molecular Biology, Russian Academy of Medical Sciences, Moscow;(2) Department of Hematology and Intensive Care, All-Russian Hematological Research Center, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Natural catalytic antibodies are known to be autoantibodies and are found in patients with different autoimmune diseases. The production of catalytic autoantibodies against DNA is demonstrated for a number of lymphoproliferative diseases. The statistical analyses performed show that this production is related to the chronic proliferation of mature B lymphocytes and correlates with the corresponding autoimmune disorders. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N o 2, pp. 204–206, February, 1996 Presented by A. I. Vorob'ev, Member of the Russian Academy of Medical Sciences |
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| Keywords: | natural catalytic antibodies autoantibodies lymphoproliferative diseases |
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