多发性硬化患者血清和脑脊液中sIL-2R及sIL-6R的研究

目的　探讨可溶性白细胞介素 2受体 (sIL 2R)和可溶性白细胞介素 6受体 (sIL 6R)在多发性硬化(MS)发病过程中的作用。方法　采用双体夹心ELISA法对 2 9例MS急性期患者及 2 0例炎性神经病患者、39例非炎性神经病患者、2 0例健康对照者脑脊液和血清中sIL 2R和sIL 6R的含量进行检测。结果　MS患者血清和脑脊液中sIL 2R、sIL 6R含量明显高于非炎性神经病组 (P <0 .0 5 )及健康对照组 (P <0 .0 1) ;MS组sIL 2R和血清sIL 6R含量与炎性神经病组比较 ,无显著性差异 ,但脑脊液中sIL 6R水平明显低于炎性神经病组 (P <0 .0 1)。结论　sIL 2R和sIL 6R在MS急性期患者体内明显升高 ,进一步证实了MS有关免疫学的发病机制 ,并为临床诊断MS提供了具有参考价值的实验室指标

Study in sIL-2R and sIL-6R level in serum and cerebraspinal fluid of the patients with multiple sclerosis (MS)

Objective To explore the immunopathogenetic role of sIL 2R and sIL 6R in MS and its clinical significance.Methods The levels of sIL 2R and sIL 6R were examined by sandwiched ELISA kits.One way ANOV was applied as a parametric approach to test different inter group levels of sIL 2R and sIL 6R in serum and CSF respectively.Results The sIL 2R and sIL 6R levels of 29 acute MS patients were significantly higher than NIND group(39 patients with non inflammatory neurological disorders) and the healthy controls. Compared with IND group (20 patients with CNS inflammatory disease),the CSF concentrations of sIL 6R in MS patients were lower,whereas the levels of sIL 2R and serum sIL 6R between MS group and IND group had no difference. Conclusions This gives further support for an enhanced immune response in patients with MS,and the measurement of sIL 2R and sIL 6R concentrations can provide an objective parameters of disease activity in patients with MS.