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The Effects of Homologous Cross-Circulation and In Situ Liver Perfusion on Fulrninant Hepatic Failure Rats |
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| Authors: | Khawar Mohsini Colin Lister Thomas M.S. Chang |
| Affiliation: | Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6 |
| Abstract: | A galactosamine-induced fulminant hepatic failure (FHF) rat model was used to study the effects of homologous cross-circulation and in situ liver perfusion. Cross-circulation with homologous donors did not significantly improve the survival time or recovery rate of grade II hepatic coma rats. Homologous in situ liver perfusion significantly improved the survival time and recovery in FHF only when started in grade II coma; it has no effect in the later stage of coma. |
| Keywords: | liver failure liver support cross-circulation liver perfusion fulminant hepatic failure hepatic coma |