Chemoradiation for localized rectal cancer: Neoadjuvant versus adjuvant approaches |
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Authors: | Lawrence S Blaszkowsky |
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Institution: | (1) Massachusetts General Hospital, 55 Fruit Street,Yawkey 7E-7200, 02114 Boston, MA, USA |
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Abstract: | For many years, adjuvant postoperative chemotherapy and radiation has been the standard of care in the United States for patients
with T3, T4, or node-positive rectal cancer. Preoperative chemoradiation has generally been reserved for situations in which
a response to therapy would allow for sphincter-preserving surgery. Recent data support the use of chemoradiation in the preoperative
setting, demonstrating improvements in tumor downstaging, treatment toxicity, rate of sphincter-preserving surgery, and pelvic
recurrence. |
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Keywords: | |
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