| 咸虾花中的牻牛烷型倍半萜内酯 |
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| 引用本文： | 梁侨丽,蒋继宏,闵知大. 咸虾花中的牻牛烷型倍半萜内酯[J]. 中国天然药物, 2010, 0(2): 104-106 |
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| 作者姓名： | 梁侨丽 蒋继宏 闵知大 |
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| 作者单位： | 南京中医药大学中药化学教研室;徐州师范大学江苏省药用植物和生物技术重点实验室;中国药科大学天然药化教研室; |
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| 摘 要： | 目的：分离鉴定斑鸠菊属植物咸虾花中的化学成分,为活性筛选提供样品。方法：90%乙醇提取,硅胶柱色谱分离,用IR,NMR,MS和X-衍射等方法确定结构。结果：分离到1个牻牛烷型倍半萜内酯,1个苯丙氨酸衍生物、1个生物碱和3个黄酮化合物,根据波谱数据和X-衍射分析分别鉴定为：incaspitolide D（1）,（S）-N-苯甲酰基苯基丙氨酸–（S）-2-苯甲酰氨基–3-苯基丙酯（（S）-N-benzoylalanine-（S）–2-benzamido-3-phenylpropyl ester,2）;吲哚-3-羧酸（indole-3-carboxylic acid,3）;香叶木素（diosmetin,4）,芹菜素（apigenin,5）和木犀草素（luteolin,6）。结论：化合物1-5是首次从咸虾花中得到,且首次通过二维NMR技术对化合物1的波谱数据进行了全归属,用X-单晶衍射确证1的立体构型。
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| 关 键 词： | 咸虾花 菊科 倍半萜内酯 incaspitolide D 香叶木素 |
A Germacrane Sesquiterpenoid from Vernonia patula |
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| LIANG Qiao-Li ,JIANG Ji-Hong ,MIN Zhi-Da. A Germacrane Sesquiterpenoid from Vernonia patula[J]. Chinese JOurnal of Natural Medicines, 2010, 0(2): 104-106 |
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| Authors: | LIANG Qiao-Li JIANG Ji-Hong MIN Zhi-Da |
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| Affiliation: | LIANG Qiao-Li 1,JIANG Ji-Hong 2,MIN Zhi-Da 3 1 Department of Chinese Medicinal Chemistry,Nanjing University of Chinese Medicine,Nanjing 210046,2 Key Laboratory of Biotechnology for Medicinal Plant of Jiangsu Province,Xuzhou Normal University,Xuzhou 221116,China 3Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | AIM:To elucidate the chemical constituents of the whole plant of Vernonia patula and provide samples for activity screening.METHODS:Column chromatography was used and the structures were determined by IR,NMR and MS spectral analysis,X-ray analysis and comparison of physicochemical properties.RESULTS:A germacrane sesquiterpenoid,incaspitolide D(1),along with(S)-N-benzoylphenylalanine-(S)-2-benzamido-3-phenyl-propyl ester(2),indole-3-carboxylic acid(3),apigenin(4),diosmetin(5)and luteolin(6)was isolated.CONCL... |
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| Keywords: | Vernonia patula Compositae Sesquiterpenoid Incaspitolide D Diosmetin |
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