| 短时受精联合早期补救性卵细胞胞质内单精子注射在完全受精失败周期的临床应用 |
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| 引用本文： | 张宁媛,孙海翔,胡娅莉,王玢,徐志鹏.短时受精联合早期补救性卵细胞胞质内单精子注射在完全受精失败周期的临床应用[J].中华男科学杂志,2009,15(6):538-541. |
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| 作者姓名： | 张宁媛 孙海翔 胡娅莉 王玢 徐志鹏 |
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| 作者单位： | 南京大学医学院附属鼓偻医院生殖医学中心,江苏,南京,210008 |
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| 摘 要： | 目的:评估短时受精联合早期补救性卵细胞胞质内单精子注射(ICSI)术在完全受精失败周期的应用结局。方法:10例体外受精-胚胎移植(IVF-ET)周期获取的卵细胞随机分组,分别采用短时受精与过夜受精,比较受精率与胚胎质量。105例常规IVF-ET周期短时受精后,行极体观察,早期判断完全受精失败后行补救性ICSI术,报道临床结局。结果:3h短时受精与过夜受精在受精率与胚胎质量上无明显差异(P>0.05)。短时受精联合早期受精失败补救后,临床妊娠率为53.3%,种植率为38.0%,出生婴儿64名。结论:短时受精联合早期补救性ICSI对常规IVF-ET周期完全受精失败患者的临床结局有明显改善。
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| 关 键 词： | 体外受精-胚胎移植 卵细胞胞质内单精子注射 补救性 短时受精 |
Combination of Short-Period Sperm-Oocyte Coincubation and Early Rescue Intracytoplasmic Sperm Injection After Total Failure of in Vitro Fertilization |
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| ZHANG Ning-yuan,SUN Hai-xiang,HU Ya-li,WANG Bin,XU Zhi-peng.Combination of Short-Period Sperm-Oocyte Coincubation and Early Rescue Intracytoplasmic Sperm Injection After Total Failure of in Vitro Fertilization[J].National Journal of Andrology,2009,15(6):538-541. |
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| Authors: | ZHANG Ning-yuan SUN Hai-xiang HU Ya-li WANG Bin XU Zhi-peng |
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| Institution: | ZHANG Ning-yuan,SUN Hai-xiang,HU Ya-li,WANG Bin,XU Zhi-peng Reproductive Medicine Center,Drum Tower Hospital Affiliated to Nanjing University School of Medicine,Nanjing,Jiangsu 210008,China |
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| Abstract: | Objective:To evaluate the outcome of the combination of short-period sperm-oocyte coincubation with early rescue intracytoplasmic sperm injection (ICSI) after complete failure of in vitro fertilization (IVF). Methods: We used short-period sperm-oocyte coincubation and overnight fertilization for the oocytes obtained from 10 IVF-ET cycles, and compared the fertilization results and embryo quality. We conducted polar body observation following short-period sperm-oocyte coincubation for 105 conventional IVF cy... |
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| Keywords: | in vitro fertilization rescue intracytoplasmic sperm injection short-period fertilization |
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