| RNAi逆转肿瘤多药耐药的研究进展 |
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| 引用本文： | 张艳红,吴晴. RNAi逆转肿瘤多药耐药的研究进展[J]. 中国癌症杂志, 2007, 17(2): 160-164 |
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| 作者姓名： | 张艳红 吴晴 |
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| 作者单位： | 上海交通大学附属上海市第一人民医院肿瘤科,上海,200080 |
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| 摘 要： | RNA干扰是真核生物中普遍存在的一种自然现象，利用双链RNA（double—stranded RNA，dsRNA）诱发宿主细胞同源mRNA降解，从而抑制特异目的基因表达。恶性肿瘤的多药耐药（muhidrug resistance，MDR）是恶性肿瘤化疗失败的主要原因。本文以恶性肿瘤多药耐药机制的阐述为线索，综述了RNAi技术在逆转肿瘤多药耐药的研究进展。
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| 关 键 词： | 多药耐药 化疗 |
| 文章编号： | 1007-3639（2007）02-0160-05 |
| 收稿时间： | 2006-08-03 |
| 修稿时间： | 2006-12-04 |
Advance in the study of reversing multidrug resistance by RNAi |
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| ZHANG Yan-hong,WU Qing. Advance in the study of reversing multidrug resistance by RNAi[J]. China Oncology, 2007, 17(2): 160-164 |
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| Authors: | ZHANG Yan-hong WU Qing |
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| Abstract: | RNAi is a very common phenomenon in eucaryon.Double-stranded RNA(dsRNA) can be used to induce degradation of homologous mRNA in the host cell and then suppression of specific gene expression.Multidrug resistance(MDR) against anticancer drugs is one of the major problems in terms of chemotherapy failure.In this review,we summarized the advance in the area how multidrug resistance against anticancer drugs is reversed by RNAi. |
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| Keywords: | RNAi |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
