Characteristics of insulin-induced hyperphagia in the golden hamster |
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Authors: | David DiBattista |
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Affiliation: | 1. University of Waterloo, Department of Psychology, Waterloo, Ontario Canada;2. Hospital for Sick Children, Research Institute, Toronto, Ontario Canada |
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Abstract: | Two experiments were performed to investigate in some detail the behavioural and metabolic effects of the administration of regular insulin to golden hamsters. In Experiment 1 dose-response curves describing the effects of insulin upon both food intake and plasma glucose (PG) were generated. Dosages of less than 20 units/kg did not cause increases in food intake, while dosages of 10 units/kg or greater produced significant hypoglycemia at +6 hr post-injection. There was also a significant inverse linear relationship (r=?.528) between individual hamsters' food intakes and PG levels over the range of insulin dosages. It Experiment 2, insulin (30 units/kg) caused increases in meal frequency but not in meal size, and hyperphagia developed within +3 hr of insulin administration. When food was not available, insulin caused PG levels to fall below control levels at +1 hr and to remain depressed until at least +6 hr post-injection. However when hamsters were allowed to eat, PG did not fall significantly below control levels until +3 hr and began to recover at +5 hr post-injection. Results are discussed in relation to several apparent peculiarities in the hamster's behavioural response to regular insulin, specifically the small magnitude and the slow development of insulin-induced hyperphagia, and the hamster's relative insensitivity to the hyperphagic effect of insulin. |
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Keywords: | Golden hamster Insulin Glucose Hypoglycemia Hyperphagia |
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