Area postrema/nucleus of the solitary tract ablations: Analysis of the effects of hypophagia |
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Authors: | Jon N Kott Christine L Ganfield Nancy J Kenney |
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Institution: | University of Washington, Seattle, WA 98195 USA |
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Abstract: | The effect of hypophagia following lesions of the area postrema and caudal-medial aspect of the nucleus of the solitary tract (AP/cmNTS) on body-weight, water intake and preference for palatable diets was examined. Following AP/cmNTS ablation, rats reduced pelleted-food intake to a degree which was sufficient to account for the weight loss and increased water:food ratios observed. Restricting food intakes of intact rats to levels taken by lesioned animals resulted in similar weight losses and increased water:food ratios. When offered both pelleted food and milk, lesioned rats took more calories as milk than did previously food-restricted intact rats. Thus, the hypophagia of AP/cmNTS lesioned rats does not account for their increased preference for milk diets. Lesioned rats ate less high-fat diet than did intact or sham-lesioned controls and did not increase their intakes when this diet was sweetened. At autopsy, retroperitoneal and epididymal fat-pad weights accounted for less of the total body weight of lesioned animals than controls suggesting that body-fat levels are reduced following AP/cmNTS ablation. |
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Keywords: | Area postrema Brain-stem lesions Nucleus of the solitary tract Food intake Water intake Body-weight regulation Body fat Liquid diet Food restriction High-fat diet |
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