Effect of the herbal medicine Inchin-Ko-To for serum bilirubin in hepatectomized patients |
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Authors: | Kaiho Takashi Tsuchiya Shunichi Yanagisawa Shinji Takeuchi Osamu Togawa Akira Okamoto Ryo Saigusa Naoki Miyazaki Masaru |
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Institution: | Department of Surgery, Kimitsu Chuo Hospital, 1010 Sakurai, Kisarazu City, Chiba, 292-8535 Japan. kaihot@aa.pial.jp |
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Abstract: | BACKGROUND/AIMS: Persistent hyperbilirubinemia is a symptom of postoperative liver failure after hepatectomy. We examined the effectiveness of a herbal medicine, Inchin-Ko-To (ICKT), on postoperative serum bilirubin levels in patients undergoing liver resection. METHODOLOGY: Patients were divided into two groups. ICKT group (n=50), 7.5g of ICKT was administered orally from three days before the operation and it continued after the operation. Control group (n=50), ICKT was not administered perioperatively. RESULTS: There was no significant difference between the two groups in postoperative serum total bilirubin levels, but in indirect bilirubin, the ICKT group showed significant decrease compared with the control group. Decreasing effect of postoperative serum bilirubin levels was much more conspicuous when a large amount of liver parenchyma was resected. In that subgroup of patients, serum all bilirubin subdivisions significantly decreased in the ICKT (n=12) group compared with controls (n=11). CONCLUSIONS: ICKT may be an effective and fresh agent in postoperative management of liver resection by its potent choleretic effect. |
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