| 低剂量辐射诱导的远期兴奋效应研究 |
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| 引用本文： | 王献理,孙晓玲,吕彩霞,张海英. 低剂量辐射诱导的远期兴奋效应研究[J]. 中华放射医学与防护杂志, 1997, 17(4): 248-249 |
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| 作者姓名： | 王献理 孙晓玲 吕彩霞 张海英 |
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| 作者单位： | 白求恩医科大学放射医学研究所 |
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| 摘 要： | 探讨低剂量电离辐射（Ｄ１）诱导兴奋效应的远期效应及其对子代的影响。方法以小鼠为实验材料，观察经Ｄ１剂量照后７５天交配所生的小鼠发育指标并测定成熟后免疫功能，对其亲代受照鼠Ｄ１剂量作用后８０天观察非程序ＤＮＡ合成（ＵＤＳ）值。结果Ｄ１照后８０天时对射线诱导的ＤＮＡ损伤修复能力提高，仔鼠出生后死亡率低，体重增加，开眼时间提前。结论说明Ｄ１剂量照射后远期某些指标表现出兴奋效应，而且可以在Ｆ１中显现，但仔鼠成熟后这种反应消失。
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| 关 键 词： | 生殖遗传学 低剂量辐射 兴奋效应 |
| 收稿时间： | 1996-05-09 |
| 修稿时间： | 1996-09-23 |
Studies on hormesis induced by long term low dose ionizing radiation |
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| Affiliation: | Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, 130021, China;Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, 130021, China;Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, 130021, China;Institute of Radiation Medicine, Norman Bethune University of Medical Sciences, Changchun, 130021, China |
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| Abstract: | Objective To study the effects of adaptive response induced by long term low dose ionizing radiation (D 1). Method We examined lethality,body weight,immune function of offspring mice and so on,and examined the UDS in mouse spleen cells induced by ultraviolet 80 days after exposure to D 1.Results The UDS in mouse spleen cells induced by ultraviolet increased in 80 days after exposure to D 1,the lethality of offspring mice decreased,body weight increased,and time of opening eyes was ahead of time. Conclusion All above results indicated that some of tests can show long term hormesis and when the offspring mice grew up,the hormesis disappeared. |
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| Keywords: | Low dose irradiation Hormesis Germ genetics |
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