Effect of Losartan on the Cardiac and Renal Function in Patients With Chronic Heart Failure |
| |
Authors: | Hongmei Tan Bin Hu Yuying Li Shanjun Zhu |
| |
Affiliation: | Hongmei Tan1,Bin Hu2,Yuying Li1,Shanjun Zhu11 Department of Cardiovascular Internal Medicine,Xinqiao Hospital,The Third Military Medical University,Chongqing 400037,China.2 Department of Cardiovascular Internal Medicine,Renhe Hospital,Three Gorges University,Yichang Hubei 443001,China |
| |
Abstract: | Objectives To explore the effect of losartan on cardiac and renal function in patients with chronic heart failure (CHF). Methods Sixty-five patients with CHF were divided into two groups using a randomized, control and single blind method: losartan group (n=30) and convention group (n=35), with a treatment course of 8 weeks for both groups. The concentrations of cystatin C (cys C) in serum, microamount albumin (MA) in urine were measured by immunoturbidimetry. The concentration of aquaporin-2(AQP-2)was determined by enzyme-linked-immunosorbent assay (ELISA) and the heart contractile function was measured by echocardiography before and after treatment respectively. Results Comparing with routine treatment group, left ventricular end-diastolic dimension (LVEDd) decreased significantly, while left ventricular ejection fraction(LVEF)and left ventricular fractional shortening (LVFS) increased significantly in losartan group. The levels of cys C in serum and MA, AQP-2 in urine were significantly lower in losartan group than in routine treatment group. Conclusion Losartan can improve cardiac and renal function in patients with CHF. |
| |
Keywords: | heart failure cardiac function renal function losartan |
本文献已被 CNKI 维普 万方数据 等数据库收录! |
|