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| 严重挤压伤大鼠早期心脏损伤的某些发病机制的探讨 | |
| 引用本文： | 刘水平,陈玉川,刘秀琴,郭薇,成建定.严重挤压伤大鼠早期心脏损伤的某些发病机制的探讨[J].中国病理生理杂志,2002,18(6):676-678. |
| 作者姓名： | 刘水平 陈玉川 刘秀琴 郭薇 成建定 |
| 作者单位： | 1. 中山医科大学法医病理学教研室, 广东广州 510080; 2. 中山医科大学核医学教研室, 广东广州 510080 |
| 基金项目： | 中山医科大学“2 11”重点学科建设基金资助 |
| 摘 要： | 目的:观察挤压伤大鼠血浆心钠素(ANP)、内皮素-1(ET-1),血清心肌肌钙蛋白I(cTnI)浓度的改变,阐明心钠素、内皮素与心脏损伤的关系。方法:复制挤压伤大鼠动物模型,全自动生化分析仪检测血清心肌酶改变,放射免疫法检测血浆ANP,ET-1水平,化学发光法检测血清cTnI浓度。结果:挤压伤后12 h,血浆ET-1显著低于对照组,血浆ANP、血清心肌酶、cTnI水平显著高于对照组,并持续48 h以上。结论:肢体挤压伤早期存在心肌细胞的损伤,其损伤可能与ANP、ET-1有重要关系。 |
| 关 键 词： | 挤压综合征 内皮素-1 心钠素 肌钙蛋白 |
| 文章编号： | 1000-4718(2002)06-0676-03 |
| 收稿时间： | 2001-01-10 |
| 修稿时间： | 2001年1月10日 |
Pathogenesis of early cardiac myocyte damage after severe crush injury |
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| LIU Shui-ping ,CHEN Yu-chuan ,LIU Xiu-qin ,GUO Wei ,CHENG Jian-ding.Pathogenesis of early cardiac myocyte damage after severe crush injury[J].Chinese Journal of Pathophysiology,2002,18(6):676-678. | |
| Authors: | LIU Shui-ping CHEN Yu-chuan LIU Xiu-qin GUO Wei CHENG Jian-ding |
| Institution: | 1. Department of Forensic Pathology, Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China; 2. Department of Nuclear Medicine, Sun Yat-sen University of Medical Sciences, Guangzhou 510080, China |
| Abstract: | AIM: To study the changes of plasma atrial natriuretic peptide(ANP), endothelin-1 (ET-1) and serum cardiac troponin I(cTnI) levels and the effects of ANP and ET-1 on myocardium in crush injury rats. METHODS: Crush injury was produced in SD rats,the serum levels of cardiac enzyme and cardiac troponin I,plasma levels of ANP and ET-1 were studied by automated biochemical analyzer,automated chemiluminescence assay and radioimmunoassay. RESULTS: The plasma ET-1 level was much lower ,the levels of plasma ANP and serum cardiac enzyme and cTnI were much higher after crush injury than those of the control group( P< 0.05). CONCLUSION:ANP and ET-1 may play an important role in cardiomyocyte injury in the early stage of crush injury. |
| Keywords: | Crush syndrome Endothelin-1 Atrial natriuretic factor Troponin |
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