芸香甙对体外冲击波碎石术时肾功能的保护作用

目的：探讨芸香甙（Ru)是否对高能冲击波引起的肾功能损伤有保护作用。方法：将27例接受体外冲击波碎石术（EWSL）的肾结石患者随机分成2组；对照组12例，术前不服用任何药物；芸香甙组15例，术前口服芸香甙。采用放射免疫法和化学比色法测定ESWL前后尿中白蛋白（ALB）、免疫球蛋白（IgG), β2-微球蛋白（β2－MG）和Tmm-Horsfall蛋白（THP）及血MDA含量、SOD活性的变化。结果：对照组病人ESWL后尿ALB、IgG、β2－MGWV分泌量和血MDA含量较ESWL前均显著升高（P＜0．01），尿THP分泌量和血SOD活性均显著降低（P＜0．01）；芸香甙组中病人尿ALB、IgG、β2－MG分泌量和血MDA含量量较ESWL前有轻微增加（P＞0．05），但与对照组病人ESWL后尿ALB,IgG、β2－MG及血MDA稔比较，明显减少（P＜0．01），尿THP分泌量及血SOD活性在ESWL后有所减少（P＞0．05），但与对照组病人ESWL后尿THP、血SOD比较，明显升高（P＜0．01）。结论：芸香甙对ESWL时肾功能损害具有保护作用。

Protection of Renal Function from Damage Due to ESWL by Rutoside

Objective:　In order to study the effects of rutoside (Ru) on renal damage induced by ESWL. Methods: 27 cases of renal stone undergone anaesthesia-free ESWL,were randomly assigned into 2 groups: the rutoside (Ru) group(n=15)and the control group (n=12). For the former group, rutoside was given orally for 3 succesive days,20 mg each time,3 times a day before ESWL,while the control group received no medication. Urinary albumin(ALB), immunoglobulin-G(IgG), β2 -microglobulin(β2 -MG) and Tamm-Horsfall protein(THP),and the serum level of superoside dismutas(SOD) and malonyldehyde(MDA) were determined before and after ESWL. Results: In the control group,a significant increase of urinary ALB、IgG、β2-MG and the serum level of MDA ,and a marked decrease of urinary THP and the serum level of SOD (P<0.01) were noted after ESWL .While there was a significant decrease of urinary ALB、IgG、β2-MG and the serum level of MDA, and a marked increase of urinary THP and the serum level of SOD(P<0.01) in the rutoside group compared with the control group. Conclusion: the results suggest that rutoside has protective effect on renal damage induced by ESWL.