| 急性非淋巴细胞白血病祖细胞集落形成作三尖杉酯碱药物敏感试验与疗效观察 |
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| 引用本文： | 朱文辉,沈泽霜,凌柱三. 急性非淋巴细胞白血病祖细胞集落形成作三尖杉酯碱药物敏感试验与疗效观察[J]. 中南大学学报(医学版), 1989, 0(3) |
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| 作者姓名： | 朱文辉 沈泽霜 凌柱三 |
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| 作者单位： | 湖南医科大学第二附属医院内科(朱文辉，沈泽霜)，湖南医科大学第二附属医院内科(凌柱三) |
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| 摘 要： | 应用PHA—LCM刺激的甲基纤维素体系进行了25例ANLL骨髓细胞去T细胞后的CFU-L培养及Har和Adr药物敏感试验。发现CFU-L体外对Har敏感性与用Har治疗的病人疗效相关,表明Har体外药敏试验能提示临床疗效、CFU-L对Adr的敏感性与Har具有高度一致性。
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| 关 键 词： | 白血病 集落形成单位测定 三尖杉酯碱类 药物疗法 |
OBSERVATION ON DRUG SENSITIVITY AND EFFICACY OF HARRINGTONINE BY COLONY FORMING UNIT IN ACUTE NONLYMPHOCYTIC LEUKEMIA |
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| Zhu Wenhui Shen Zeshuang Lin Zhusan. OBSERVATION ON DRUG SENSITIVITY AND EFFICACY OF HARRINGTONINE BY COLONY FORMING UNIT IN ACUTE NONLYMPHOCYTIC LEUKEMIA[J]. Journal of Central South University. Medical sciences, 1989, 0(3) |
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| Authors: | Zhu Wenhui Shen Zeshuang Lin Zhusan |
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| Affiliation: | Zhu Wenhui Shen Zeshuang Lin ZhusanDepartment of Internal Medicine,The Second Affiliated Hospital,Hunan Medical University |
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| Abstract: | With PHA-LCM stimulated methylcellulose system, the culture results of bone marrow cells deprived of T-lymphocyte, of 25 patients with ANLLwere studede in this article.The morphology and ability of self-renewal of the colony cells suggested that the colonies were originated from leukemic progenitor cells (CFU-L) .The number of colony growth was linearly correlated with that of cells plated.It was found that the colony production rate was much higher in type M5 than that in M1-3 according to the FAB classification.The sensitivity of CFU-L to harringtonine (Har) in vitro was well correlated with the results of clinical treatment when the drug concentration was 0.5ug/ ml.This result suggested that the in vitro sensitivity to Har could be used as a predictive index for ANLL patients treated with Har.We also found that the in vitro sensitivity of CFU-L to adrimycin was very similar to that of Har. |
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| Keywords: | leukemia colony-forming units assay harringtonine drug therapy |
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