In vitro antimicrobial activity of aromatic diamidines and diimidazolines related to pentamidine |
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| Authors: | Donkor I O Clark A M |
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| Affiliation: | Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee, Memphis 38163, USA. |
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| Abstract: | Geometric isomers of pentamidine analogues were screened for antimicrobial activity in vitro. cis isomers demonstrated good antibacterial activity compared to their trans counterparts. Both isomers were moderately active against opportunistic pathogens that afflict AIDS patients with minimum inhibitory concentrations in the range of 3.12-12.5 microg/mL. |
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