多发性硬化斑块周围正常表现白质的磁敏感加权成像及动态磁敏感增强灌注成像

目的 通过定量测量多发性硬化(MS)患者白质斑块周围"正常表现白质"(normal-appearing white matter,NAWM)脑铁浓度和灌注参数来评估其微循环变化与铁沉积的关系.方法 31例MS患者进行MR检查,包括磁敏感加权成像(susceptibility-weighted imaging,SWI),...

Susceptibility-weighted imaging and dynamic susceptibility contrasted MR perfusion imaging of normal-appearing white matter around plaques in multiple sclerosis

Objective：To determine the correlation between iron deposit and perfusion by quantificationally measuring the phase value and perfusion indices in normal-appearing white matter（NAWM） in multiple sclerosis（MS） patients.Materials and Methods：Thirty-one clinically proven MS cases were performed with susceptibility-weighted imaging（SWI） and dynamic susceptibility contrasted MR perfusion imaging（DSC-PI）.Thirty age-matched healthy volunteers were participated in this study as a control.Features of MS plaques in filtered phase images（FPI） were first assessed.The measurements of phase values and perfusion parameters（including CBF and CBV） were taken and compared by using paired t test,and the correlations between phase values and perfusion parameters,as well as phase values and EDSS was respectively evaluated by using Pearson correlative analysis.Results：In 31 cases of MS,the round or oval hypointense foci with or without small veins were considered as the characteristic finding of MS plaques.In comparison with the controls,the phase values of NAWM surrounding MS plaques were significantly lower in the MS group（P0.05）.Pearson correlation analysis revealed a significant correlation between the phase values of bilateral parietal NAWM and EDSS（P0.05）.As for the bilateral parietal and frontal NAWM,their phase values also significantly correlated with the rCBF（P0.05）.Conclusion：The phase values of NAWM in the MS patients varied with the cerebral perfusion,which also correlated with the EDSS,and could be used to evaluate the course changes of MS patients.